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. 2016 Aug 18;9:78. doi: 10.1186/s13041-016-0255-x

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — Differential effect of a PK2 antagonist PKR#7 on the locomotor activity and arousal levels in mice and monkeys. a. PKR#7 significantly increased the locomotor activity of the mice (N = 16, P < 0.05, Two-way ANOVA, *, P < 0.05, by Bonferroni’s post hoc test). b. PKRA83 significantly increased the wake time of the mice (N = 6, Two-way ANOVA, *, P < 0.05, by Bonferroni’s post hoc test). The inserts of A and B show the PKR#7 increased the locomotor activity and the wake minutes during the six hours day time period, respectively (**, P < 0.01, paired t-test). c. PKR#7 significantly increased the sleep time of the monkeys (N = 9, *, P < 0.05, paired t-test)