Table 3.

Estimated differences in the changes in proteinuria, serum creatinine, estimated glomerular filtration rate, serum uric acid, and systolic and diastolic blood pressure between no clopidogrel and clopidogrel groups during the 24-week treatment period (linear mixed-effects model)

Characteristic	No clopidogrel			Clopidogrel			Differences
	n	Mean	95% CI	n	Mean	95% CI	Mean	95% CI	F	P
Changes in proteinuria from baseline (g/24 h) (weeks)
4	200	−0.18	−0.27 to −0.09	199	−0.14	−0.23 to −0.05	−0.07	−0.26 to 0.12	0.77	0.380
12	195	−0.17	−0.27 to −0.06	195	−0.07	−0.18 to 0.04
24	182	−0.40	−0.50 to −0.31	183	−0.36	−0.46 to −0.26
Changes in serum creatinine from baseline (μmol/L) (weeks)
4	200	0.87	−0.45 to 2.19	199	1.09	−0.23 to 2.42	3.09	−0.35 to 6.53	0.13	0.716
12	195	0.85	−0.82 to 2.53	195	1.39	−0.29 to 3.07
24	182	0.58	−1.13 to 2.28	183	0.83	−0.88 to 2.53
Changes in eGFR from baseline (ml·min−1·1.73 m−2) (weeks)
4	200	−1.06	−2.30 to 0.18	199	−1.11	−2.35 to 0.13	−1.19	−4.42 to 2.03	0.81	0.368
12	195	−0.41	−1.96 to 1.13	195	−1.65	−3.20 to −0.11
24	182	−0.30	−1.90 to 1.29	183	−1.27	−2.86 to 0.33
Changes in serum uric acid from baseline (μmol/L) (weeks)
4	196	−24.99	−42.67 to −7.30	198	−24.44	−42.03 to −6.85	−5.99	−27.33 to 15.36	0.54	0.461
12	191	−36.11	−46.20 to −26.03	194	−28.78	−38.78 to −18.79
24	178	−34.24	−44.90 to −23.57	183	−26.61	−37.15 to −16.07
Changes in systolic blood pressure from baseline (mmHg) (weeks)
4	200	−0.21	−1.28 to 0.87	199	−0.19	−1.27 to 0.89	−0.88	−3.85 to 2.09	0.05	0.829
12	193	−0.42	−1.72 to 0.88	192	−0.28	−1.58 to 1.02
24	177	−0.24	−1.71 to 1.23	180	0.11	−1.36 to 1.57
Changes in diastolic blood pressure from baseline (mmHg) (weeks)
4	200	−0.19	−1.02 to 0.64	199	−0.73	−1.56 to 0.10	1.07	−1.00 to 3.15	2.93	0.090
12	193	−0.44	−1.41 to 0.54	192	−1.14	−2.13 to −0.16
24	177	0.45	−0.58 to 1.47	180	−1.14	−2.17 to −0.12

CI: Confidence interval; eGFR: Estimated glomerular filtration rate.