Table 3. Characteristics of Women Who Underwent RRSO After BRCA Testing.
| No. (%) | ||||
|---|---|---|---|---|
|
|
||||
| Characteristic | No RRSO (n = 757) | RRSO (n = 206) | Adjusted OR (95% CI) | P Value |
| BRCA result | ||||
| Uninformative | 605 (87.7) | 85 (12.3) | 1 [Reference] | |
| Positive | 52 (30.4) | 119 (69.6) | 28.1 (16.2-48.6) | <.001 |
| True-negative | 100 (98.0) | 2 (2.0) | 0.1 (0.0-0.6) | .01 |
| Age at RRSO or survey, ya | ||||
| <40 | 106 (79.1) | 28 (20.9) | 1 [Reference] | |
| 40-49 | 216 (71.3) | 87 (28.7) | 2.6 (1.2-5.6) | .01 |
| 50-59 | 237 (78.7) | 64 (21.3) | 2.1 (1.0-4.6) | .06 |
| ≥60 | 198 (89.6) | 23 (10.4) | 0.8 (0.3-2.0) | .63 |
| Race | ||||
| Nonwhite | 120 (78.9) | 32 (21.1) | 1 [Reference] | |
| White | 636 (78.5) | 174 (21.5) | 1.2 (0.6-2.2) | .59 |
| Ashkenazi Jewishb | ||||
| No | 418 (78.3) | 116 (21.7) | 1 [Reference] | |
| Yes | 300 (78.7) | 81 (21.3) | 0.9 (0.6-1.4) | .63 |
| Income-producing assets, $ | <.001 | |||
| ≤100 000 | 148 (85.5) | 25 (14.5) | 1 [Reference] | |
| 100 001-500 000 | 255 (78.9) | 68 (21.1) | 1.8 (0.9-3.5) | .11 |
| 500 001-1 000 000 | 100 (74.1) | 35 (25.9) | 3.3 (1.5-7.4) | .004 |
| ≥1 000 001 | 254 (76.7) | 77 (23.3) | 3.5 (1.7-7.3) | <.001 |
| Testing sitec | ||||
| SFGH | 55 (88.7) | 7 (11.3) | ||
| Diller | 702 (77.9) | 199 (22.1) | ||
| BMI, mean (SD) | 24.4 (4.8) | 25.0 (5.6) | 1.0 (1.0-1.1) | .84 |
| No. of live births | ||||
| Mean (SD) | 1 (1) | 2 (1) | ||
| 0 | 226 (82.8) | 47 (17.2) | 1 [Reference] | |
| 1 | 163 (81.5) | 37 (18.5) | 1.3 (0.7-2.5) | .46 |
| ≥2 | 362 (74.9) | 121 (25.1) | 2.3 (1.3-3.9) | .003 |
| Personal history of breast cancer | 476 (77.4) | 139 (22.6) | 2.2 (1.3-3.7) | .004 |
| First-degree relative with breast cancer | 303 (75.4) | 99 (24.6) | 1.12 (0.8-1.8) | .48 |
| First-degree relative with ovarian cancer | 102 (61.1) | 65 (38.9) | 4.2 (2.4-7.4) | <.001 |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); Diller, Helen Diller Family Comprehensive Cancer Center; OR, odds ratio; RRSO, risk-reducing salpingo-oophorectomy; SFGH, San Francisco General Hospital.
a
Age at RRSO for respondents reporting RRSO. For respondents who did not report RRSO, age at survey.
b
Forty-seven participants responded that they did not know whether they had Ashkenazi Jewish ancestry.
c
Testing site was not included in the final multivariate model because of the low absolute number of RRSOs (n = 7) in the SFGH population per the statistical analysis plan described in the “Methods” section.