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. 2012 May 29;5(3):94–97. doi: 10.1258/om.2012.110014

Table 1.

Pregnancy-associated factors influencing multiple sclerosis relapse rate

Factors associated with an increased number of relapses
 Postpartum period
 Drop in E2 (oestradiol) and E3 (oestriol) serum levels
 Infections
 Pre-eclampsia?
Factors associated with a low number of relapses
 Second and third trimester of pregnancy
 High E2, E3 and progesterone levels
 Breastfeeding