Table 3.

Comparison of gene expression between resistant and non-resistant cell lines for adenocarcinoma and squamous cell carcinoma [65], and H3K9K14ac during treatment with an HDAC inhibitor for NSCLC cell lines [85]

Gene expression
Adenocarcinoma
		P-value	Non-resistant cell lines	resistant cell lines
SFRP1		4.64 × 10 −4	611.06	>92.60
DKK3		6.73 × 10−2	263.27	>30.59
Squamous cell carcinoma
SFRP1		7.42 × 10 −3	304.53	>49.53
DKK3		4.61 × 10−1	261.38	<506.25
Histone modification (H3K9K14ac)
		P-value	0 hours	2 hours
	(A549)	2.90 × 10 −2	−1.29	<−0.52
SFRP1	(H1299)	4.06 × 10 −2	−2.51	<−1.85
	(CL1-1)	8.71 × 10−1	−1.38	<−1.34
	(A549)	6.19 × 10−1	−1.17	<−1.01
DKK3	(H1299)	1.98 × 10 −3	−1.70	<−0.48
	(CL1-1)	1.48 × 10−1	−0.59	>−1.13
	(A549)	4.74 × 10−1	−1.70	<−1.37
TACSTD1	(H1299)	1.51 × 10−1	−2.61	<−2.20
	(CL1-1)	8.62 × 10−1	−2.03	>−2.09
	(A549)	1.71 × 10 −3	−2.44	<−1.05
SALL4	(H1299)	5.23 × 10−1	−2.62	>−2.86
	(CL1-1)	1.03 × 10 −4	0.97	>−0.59

Significant P-values (<0.05) are shown in bold