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. 2016 Aug 12;9(Suppl 1):37. doi: 10.1186/s12920-016-0197-2

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Integration of methylation pattern and gene expression profile for FCGR2A. The CpG marker cg24422489 is located at the promoter region (244 nt. in front of the transcription start site) of FCGR2A. a The methylation pattern of cg24422489 and gene expression profile of FCGR2A are negatively correlated. In addition, they are altered in FC, KD1 and KD3 samples. For qPCR curve, the X axis unit is the expression ratio of FCGR2A to the internal control gene, 18S. Histogram and curve are presented as mean + SEM. b For an un-biased result, we did 10,000 re-sampleings individually in FC, KD1 and KD3 sets followed by deriving the Pearson’s correlation coefficient. The result shows that methylation pattern is positively correlated with ΔCt values. Therefore, hyper-methylation represses gene expression. The qPCR result is from the previous study [16]