Fig. 6.

Distribution of Crohn’s disease association scores. a Distribution of CDA scores of genes derived from the solution matrix W. The scores are calculated by averaging the best-30 NMTF solutions. b Distribution of standard deviations of CDA scores of each gene. By the definition of standard deviation, the value cannot exceed 0.509, because the CDA score is ranged from 0 to 1. c Cumulative distribution of CDA scores for Crohn’s disease genes and other unknown genes. Note that the newly annotated and unannotated genes are identically constrained in the disease gene constraint metrix W ₀