Figure 3.

Clonal relatedness between LCIS and ILC. Representation of the anatomical locations/breast quadrants of samples subjected to targeted massively parallel sequencing from cases for which three lesions (i.e., LCIS–LCIS–ILC) were analyzed or for cases where distinct somatic mutations between lesions were found. Clonally related lesions are indicated in orange, lesions in blue represent those without clonal relationship with any other lesion from the patient. ILC, invasive lobular cancer; LCIS, lobular carcinoma in situ.