Table 4.

Univariate and multivariate analyses of factors influencing recurrent free survival

Factor	Univariate	p	Multivariate	p
	HR (95% CI)		HR (95% CI)
Sex (female vs. male)	1.66 (0.69–3.98)	0.245
Age	1.02 (0.98–1.07)	0.324
Size (pathological)	1.04 (1.02–1.06)	<0.001	1.24 (0.98–1.07)	0.281
Size of part solid (CT)	1.01 (0.99–1.04)	0.307
CT findings (part-solid vs. solid)
	5.89 (1.39–24.94)	0.016	4.05 (0.46–35.95)	0.210
SUVmax	1.19 (1.10–1.29)	<0.001	0.97 (0.80–1.16)	0.703
IFP	1.07 (1.03–1.12)	0.001	1.06 (0.995–1.12)	0.074
Lymphatic vessel invasion
	3.81 (2.39–6.07)	<0.001	2.77 (1.02–7.49)	0.045
Vascular vessel invasion
	4.26 (2.37–7.66)	<0.001	1.42 (0.57–3.55)	0.454
Pleural invasion	1.94 (1.42–2.63)	<0.001	1.12 (0.71–1.78)	0.627
Grade	1.86 (1.15–3.01)	0.012	0.75 (0.33–1.71)	0.493
Ki-67	8.33 (1.30–53.3)	0.025	1.89 (0.06–58.88)	0.716
MVD	1.01 (0.98–1.06)	0.402
T (pathological)	1.96 (1.53–2.57)	<0.001	1.13 (0.64–2.00)	0.676
N (pathological)	2.38 (1.47–2.86)	<0.001	0.74 (0.29–1.86)	0.514

HR: Hazard ratio; CI: confidence interval; CT: computed tomography; SUVmax: maximal standardized uptake value; IFP: interstitial fluid pressure; MVD: microvessel density