Fig. 2.

When the cutoff level of our graphic assay was set as y = −2x + 80 according to the proportional formula, the number of anaplastic lymphoma kinase fusion-positive (AP) lesions falling under this formula line was 88.9% (24/27) (A), whereas that for exon 19 was 29.5% (13/44) (B) and for exon 21 was 19.0% (12/63) (C). Significant differences were found between exon 19 and AP lesions (p <0.01) and between exon 21 and AP lesions (p <0.01). The area under the receiver operating characteristic curve for tumor disappearance rate (TDR) in AP lesions was 0.70 (D).