Table 2.
Imaging characteristics of ALK fusion-positive and negative nodules on HRCT
| ALK fusion-positive | ALK fusion-negative | p-value | |
|---|---|---|---|
| Total number | 27 | 209 | |
| Size (mm), (range) | 20.7 ± 14.1 (6–71) | 27.4 ± 13.8 (6–100) | p <0.01 |
| ≤20 | 20 (74.1%) | 76 (36.4%) | p <0.01 |
| >20 | 7(25.9%) | 133(63.6%) | p <0.01 |
| Air bronchogram | 19 (70.4%) | 156 (74.6%) | p = 0.374 |
| Pleural indentation | 19 (70.4%) | 141 (67.5%) | p = 0.487 |
| Spiculation | 22 (81.5%) | 156 (74.6%) | p = 0.941 |
| TDR (%) | 22.8 ± 24.8 | 44.8 ± 33.2 | p <0.01 |
| Solid (TDR ≤20%) | 15 (55.6%) | 64 (30.6%) | p = 0.01 |
| Partial solid (20< TDR <75%) | 10 (37.0%) | 93 (44.5%) | p = 0.46 |
| Least solid (TDR ≥75%) | 2 (7.4%) | 52 (24.9%) | p = 0.04 |
TDR (%) = [1 – (maximum dimension of tumor in the mediastinal windows/ maximum dimension of tumor in the lung windows)] × 100. ALK: anaplastic lymphoma kinase; HRCT: high-resolution computed tomography; TDR: tumor disappearance rate