Table 3.
Imaging characteristics of ALK fusion-positive and negative nodules on HRCT (small size and solid-type pattern)
| ALK fusion-positive | ALK fusion-negative | p-value | |
|---|---|---|---|
| Size ≤20 mm | |||
| Total number | 20 (74.1%) | 76 (36.3%) | p <0.01 |
| Size (mm) | 13.9 ± 3.8 | 14.6 ± 3.5 | p = 0.47 |
| Air bronchogram | 13 (65.0%) | 41 (53.9%) | p = 0.38 |
| Pleural indentation | 13 (65.0%) | 37 (48.7%) | p = 0.20 |
| Spiculation | 18 (90.0%) | 41 (53.9%) | p <0.01 |
| TDR (%) | 29.4 ± 25.6 | 58.7 ± 33.8 | p <0.01 |
| Solid (TDR ≤20%) | 8 (40.0%) | 12 (15.8%) | p = 0.02 |
| Partial solid (20< TDR <75%) | 10 (50.0%) | 34 (44.7%) | p = 0.68 |
| Least solid (TDR ≥75%) | 2 (10.0%) | 30 (39.5%) | p = 0.01 |
| TDR ≤20% | |||
| Total number | 15 (55.6%) | 66 (33%) | p <0.01 |
| Size (mm) | 23.5 ± 11.4 | 34.4 ± 12.8 | p = 0.01 |
| Air bronchogram | 10 (66.7%) | 52 (78.9%) | p = 0.32 |
| Pleural indentation | 12 (80.0%) | 58 (87.9%) | p = 0.84 |
| Spiculation | 12 (80.0%) | 54 (81.2%) | p = 0.33 |
TDR (%) = [1 – (maximum dimension of tumor in the mediastinal windows/ maximum dimension of tumor in the lung windows)] × 100. ALK: anaplastic lymphoma kinase; HRCT: high-resolution computed tomography; TDR: tumor disappearance rate