Fig. 1.
Description of the system under study. (A–B) Photographs of WT, Lig4Y288C and Atm−/− mice displaying their small size compared with WT littermates of the same gender. (C) A coronal depiction of the neural stem cell compartment at E14.5, P5 and 2–3 months (adult). At E14.5, ventricular/subventricular zones (VZ/SVZ) occupy around half of the forebrain. The IZ and CP encompass the progenitor and more differentiated cells, respectively. From E11.5 to E16.5, the VZ/SVZ cells are undergoing rapid proliferation. At P5, the SVZ occupies a smaller region of the forebrain but is still actively dividing and in a dynamic state. By adulthood, the SVZ is much smaller and the neural stem and progenitor cells are less numerous and less actively dividing. (D) Sagittal representation of the adult brain showing the main regions of postnatal neurogenesis: the SVZ located close to the lateral ventricles, and the SGZ, which lies within the dentate gyrus of the hippocampus.