Fig. 4.
Endogenous level of DNA damage and apoptosis at different ages. (A) In vivo time course analysis of endogenous 53BP1 foci formation in the SVZ from E14.5 (5.5 days before birth), E17.5, P5, P15 and into adulthood (90 days post birth). Note that time 0 is the time of birth and minus numbers represent embryonic times before birth. In WT and Lig4Y228C mice, the level of DSBs diminishes with age, reaching a steady state level 2–3 months after birth, in contrast with the trend shown in mice deficient in Atm. (B) As for ‘A’, except that the analysis is carried out in the isocortex at times P5 and P15, and in adult mice. (C) In vivo time-course analysis of the endogenous level of apoptosis from the embryonic neocortex to the adult SVZ, showing the presence in the neonatal SVZ of a developmentally regulated ATM-independent apoptotic process occurring at P5. [The data is taken from reference 16.].