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Structure of NBS1 protein. NBS1 consists of FHA and BRCT1/2 regions at the N terminus and multiple protein-binding regions at the C terminus. FHA and BRCT1/2 regions are involved in the IR-induced nuclear foci via interaction with phosphoproteins. Protein-binding regions at the C terminus contain ATM-, RNF20-, MRE11-, RAD18- and RPA-binding regions, which regulate cell cycle checkpoint, DNA repair and chromatin remodeling.
