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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Trends Mol Med. 2016 Jun 23;22(8):639–641. doi: 10.1016/j.molmed.2016.06.004

Figure 1. Current Murine Models for ZIKV-Induced Fetal Abnormalities.

Figure 1

Left panel) ICR fetuses carefully injected intracerebrally exhibit viral infection of the brain and reduced brain size by 5 days post-infection. Middle panel) SJL mice infected with a Brazilian ZIKV isolate give birth to pups with whole-body growth delay and IUGR. Viral replication can be detected in fetal brains. Right panel) After ZIKV-infection of IFNAR−/− dams carrying IFNAR+/− heterozygous fetuses, the virus replicates in placental trophoblasts and neurons. Most fetuses undergo demise and resorption, while surviving fetuses exhibit IUGR.