Table 1. Clinicopathological parameters and quality scores of studies comparing HER3/HER4 positive GC with HER3/HER4 negative GC in Asian population.
| HER family members | Study | Year | Number of Patients | Sex | Age | Tumor location | Depth of invasion | LN metastasis | Distant metastasis | TNM stage | Recurrence | Lauren’s type | Vascular invasion | Quality scorea |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (male/female) | (cardia/body+antrum) | (T1+T2/T3+T4) | (N0/N1+N2+N3) | (M0/M1) | (I+II/III+IV) | (negative/positive) | (intestinal/diffuse) | (negative/positive) | ||||||
| HER3 | Hayashi | 2008 | 134(79 vs.55) | 51/28vs.43/12 | 67vs.64 | NA | NA | 21/58vs.41/14 | 64/15vs.53/2 | NA | 41/25vs.51/3 | 27/52vs.22/33 | NA | 8 |
| Zhang | 2009 | 102(14 vs.88) | NA | NA | NA | NA | NA | NA | 3/11vs.49/39 | NA | 3/11vs.57/31 | NA | 5 | |
| Wu | 2014 | 161(90 vs.71) | 73/17vs.51/20 | NA | 43/47vs.28/43 | 19/71vs.30/41 | 31/59vs.37/34 | 81/9vs.68/3 | NA | NA | 18/72vs.18/53 | 37/53vs.41/30 | 5 | |
| Tang | 2015 | 121(75 vs.46) | 52/23vs.33/13 | NA | NA | 8/67vs.3/43 | 17/58vs.14/32 | 70/5vs.42/4 | 23/52vs.13/33 | NA | 20/55vs.4/40 | NA | 5 | |
| He | 2015 | 498(103vs.395) | 70/33vs.280/115 | 60vs.58 | 52/51vs.247/148 | 13/90vs.109/286 | 23/80vs.134/261 | 86/17vs.322/73 | 26/77vs.180/215 | NA | 88/15vs.196/199 | NA | 8 | |
| HER4 | Hayashi | 2008 | 134(115vs.19) | 80/35vs.14/5 | 66vs.66 | NA | NA | 51/64vs.11/8 | 103/12vs.14/5 | 57/58vs.9/10 | 81/24vs.11/4 | 46/69vs.3/16 | NA | 8 |
| Li | 2013 | 161(110vs.51) | 82/28vs.42/9 | NA | 52/58vs.19/32 | 28/82vs.21/30 | 68/42vs.25/26 | 105/5vs.44/7 | 18/92vs.18/33 | NA | 23/87vs.13/38 | 49/61vs.29/22 | 5 | |
| He | 2015 | 498(66vs.432) | 45/21vs.305/127 | 60vs.59 | 39/27vs.260/172 | 10/56vs.112/320 | 14/52vs.143/289 | 54/12vs.354/78 | NA | NA | 56/10vs.228/204 | NA | 8 |
Abbreviations: HER: human epidermal growth factor receptor; GC: gastric cancer; vs.: versus; NA: not available; TNM: depth of invasion (T), lymph nodes metastasis (N), and presence of distant metastasis (M).
T1-T4, N0-N3, M0-M1and TNM stages are based on tumor-node-metastasis classification advocated by International Union against Cancer
Quality scorea: use the Newcastle-Ottawa scale (stars)