Table 3. Association between HER3/HER4 over-expression and overall survival (OS) in GC.

HER family members	OS	Number of studies	Number of patients	Heterogeneity		Model	OR(95%CI)	P value
				I2(%)	P value
HER3	1-year OS	5	789	0	0.78	FE	0.89(0.83,0.96)	0.002
	3-year OS	4	687	25	0.26	FE	0.70(0.62,0.80)	<0.00001
	5-year OS	3	566	44	0.17	FE	0.71(0.61,0.84)	<0.00001
HER4	1-year OS	3	566	28	0.25	FE	1.03(0.93,1.14)	0.55
	3-year OS	3	566	9	0.33	FE	1.01(0.86,1.18)	0.94
	5-year OS	3	566	0	0.52	FE	1.09(0.91,1.30)	0.37

Abbreviations: OS: overall survival; RR: risk ratio; CI: confidence interval; FE: fixed-effect model; RE: random-effect model