Table 1.
Effects of a high-fat diet and resveratrol on various biomarkers in plasma
| Parameter | Standard diet | High calorie | High calorie 1 resveratrol | Fed or Fasted |
|---|---|---|---|---|
| Free fatty acids (mequiv.) | 0.27 (0.04) | 0.59 (0.06)† | 0.53 (0.03)† | Fed |
| 0.83 (0.10) | 0.45 (0.20) | 0.54 (0.05) | Fasted | |
| Triglycerides (mg dl−1) | 76.6 (6.8) | 81.4 (6.6) | 88.2 (10.8) | Fasted |
| Cholesterol (mg dl−1) | 135 (7) | 183 (20)† | 204 (16)† | Fasted |
| Insulin (ng ml−1) | 1.77 (0.64) | 9.21 (1.95)† | 2.46 (0.47)* | Fed |
| 0.73 (0.14) | 2.70 (0.36)† | 1.06 (0.30)* | Fasted | |
| Glucose (mg dl−1) | 129.0 (5.4) | 118.3 (4.7) | 114.8 (6.3) | Fed |
| 94.5 (3.3) | 125.3 (11.6)† | 85.6 (10.3)* | Fasted | |
| IGF-I (ng ml−1) | 346 (40) | 534 (12)† | 482 (21)†‡ | Fed |
| 625 (33) | 999 (102)† | 929 (81)† | Fasted | |
| IGFBP-1 (AU) | 1.0 (0.3) | 1.7 (0.3) | 1.7 (1.0) | Fed |
| 1.0 (0.2) | 0.5 (0.3) | 0.3 (0.1)† | Fasted | |
| IGFBP-2 (AU) | 1.0 (0.2) | 0.7 (0.04) | 0.9 (0.1) | Fasted |
| Leptin (ng ml−1) | 2.0 (1.1) | 21.6 (7.2) | 11.6 (6.5) | Fasted |
| Adiponectin (μg ml−1) | 12.1 (1.6) | 9.5 (0.5) | 9.0 (0.8) | Fed |
| Amylase (Ul−1) | 2,060 (150) | 2,960 (320)† | 2,190 (230)* | Fasted |
| Ala aminotransferase (U l−1) | 347 (119) | 390 (61) | 446 (88) | Fasted |
| Asp aminotransferase (U l−1) | 448 (85) | 425 (90) | 512 (46) | Fasted |
| Creatine phosphokinase (U l−1) | 4,260 (1820) | 2,010 (810) | 2,520 (680) | Fasted |
| Lactate dehydrogenase (U l−1) | 1,530 (240) | 1,610 (170) | 2,020 (180) | Fasted |
| Alkaline phosphatase (U l−1) | 43.8 (3.4) | 44.6 (6.0) | 34.2 (1.4) | Fasted |
| Bilirubin (mg dl−1) | 0.16 (0.02) | 0.10 (0.03) | 0.16 (0.02) | Fasted |
| Albumin (g dl−1) | 2.78 (0.16) | 2.88 (0.19) | 2.66 (0.14) | Fasted |
| Creatinine (mg dl−1) | 0.54 (0.02) | 0.48 (0.04) | 0.46 (0.04) | Fasted |
| Cyclo-oxygenase (liver, AU mg−1) | 1.00 (0.14) | 0.80 (0.11) | 0.83 (0.11) | Fed |
| Citrate synthase (liver, AU mg−1) | 141 (14) | 128 (21) | 138 (11) | Fed |
| Body temperature (°C) | 34.71 (0.14) | 35.52 (0.17)† | 35.57 (0.15)† | Fed |
Values shown are mean (±s.e.m.). AU, arbitrary units; U l−1, units per litre.
*
P < 0.05 versus high calorie.
†
P < 0.05 versus standard diet.
‡
P < 0.05 versus high calorie by one-tailed Student’s t-test.