Table 2. Changes in glycemia, HOMA, insulinemia, triglyceridemia and oxidative stress markers during the oral fat load test in the studied groups.
Fasting | 2h | 4h | 6h | 8h | ||
---|---|---|---|---|---|---|
Glucose (mg/dL) | Control | 91.5±8.3 | 87.1±7.1a | 86.1±7.8a | 84.3±5.4a | 84.1±6.6a |
AO | 92.8±8.6c | 92.3±6.7c | 90.5± 8.5c | 87.4±7.0b | 86.7± 5.2b | |
Insulin (μU/mL) | Control | 5.2±2.7 | 5.1±2.6 | 4.4±2.48 | 3.5±2.8a | 3.1±1.97a |
AO | 19.7±14.2c | 15.9±7.9 8c | 13.5±9.38b,c | 9.5±7.28b,c | 8.2±6.1b,c | |
HOMA index | Control | 1.1±0.6 | 1.3±0.7 | 0.9±0.7 | 0.7±0.7 | 0.7±0.6 |
AO | 4.6±3.9c | 3.7±1.9c | 3.2±2.3c | 2.1±1.8b,c | 1.7±1.3b,c | |
C peptide (ng/mL) | Control | 1.8±0.9 | 1.6±0.9a | 1.3±0.7a | ||
AO | 2.8±1.3c | 2.5±1.2c | 2.0±0.9b,c | |||
Triglycerides(mg/dl) | Control | 68.6±21.4 | 107.9±49.1a | 122.0±59.4a | 95.1±66.4a | 65.6±20.4a |
AO | 132.8±64.6c | 178.3±67.9b,c | 216.0±73.6b,c | 148.4±49.0b,c | 111.5±36.4b,c | |
GSSG (U/mg prot) | Control | 0.45±0.08 | 0.36±0.07a | 0.31±0.07a | 0.28±0.05a | 0.23±0.05a |
AO | 0.69±0.1c | 0.43±0.09b,c | 0.38±0.08b,c | 0.33±0.82b,c | 0.26±0.84b | |
GSH (U/mg prot) | Control | 20.1±2.3 | 22.3±1.8a | 23.3±2.0a | 24.3±1.7a | 25.4±1.7a |
AO | 10.8±3.1 | 12.5±2.8b | 14.1±3.0b | 15.7±3.8b | 17.1±3.6b | |
GSSG/GSH x101 | Control | 0.25±0.05 | 0.16±0.03a | 0.13±0.03a | 0.11±0.02a | 0.09±0.02a |
AO | 0.6±0.19c | 0.35±0.07b,c | 0.27±0.06b,c | 0.22±0.49b,c | 0.15±0.41b,c | |
MDA (U/mg prot) | Control | 0.37±0.06 | 0.34±0.03a | 0.30±0.06a | 0.22±0.06a | 0.22±0.06a |
AO | 0.53±0.12c | 0.34±0.04b | 0.24±0.08b,c | 0.19±0.04b,c | 0.18±0.02b,c |
a p< 0,05 fasting vs postprandial in control group.
b p< 0,01 fasting vs postprandial in AO group.
c p< 0.01 control vs AO group.
Abbreviations: AO = abdominal obesity;GSH: reduced glutathione;GSSG = oxidizedglutathione; MDA: malonildyaldehide.
C-peptide was analyzed at time 0, 4 and 8 hours.