Table 2. Event rates for all-cause and cause-specific ESRD.
| All-cause ESRD | Cause-specific ESRD | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Risk factor | ADPKD | VN | DN | Other disease | |||||
| Categories | Person years | # Deaths | N | Event rate* | Event rate* | ||||
| Sex | Women | 1,684,358 | 11,079 | 158 | 9.38 | 1.13 | 1.66 | 2.20 | 4.39 |
| Men | 1,357,254 | 11,383 | 245 | 18.05 | 1.25 | 5.08 | 3.61 | 8.10 | |
| Age [years] | < 30 | 860,027 | 461 | 17 | 1.98 | 0.23 | 0.12 | - | 1.63 |
| 30–39 | 744,028 | 1,048 | 58 | 7.80 | 1.08 | 0.81 | 1.21 | 4.70 | |
| 40–49 | 616,195 | 2,384 | 110 | 17.85 | 2.11 | 2.60 | 5.03 | 8.11 | |
| 50–59 | 460,092 | 4,564 | 103 | 22.39 | 1.74 | 5.87 | 4.78 | 10.00 | |
| 60–69 | 255,646 | 6,765 | 94 | 36.77 | 1.96 | 14.47 | 8.61 | 11.73 | |
| ≥70 | 105,625 | 7,240 | 21 | 19.88 | - | 9.47 | 1.89 | 8.52 | |
| Smoking status | Non-smokers | 2,149,272 | 16,166 | 259 | 12.05 | 1.12 | 2.65 | 2.28 | 6.00 |
| Smokers | 892,341 | 6,296 | 144 | 16.14 | 1.34 | 4.48 | 4.15 | 6.16 | |
| BMI [kg/m2] | <18.50 | 96,673 | 485 | 1 | 1.03 | - | - | - | 1.03 |
| 18.50 - < 25 | 1,700,328 | 9,103 | 133 | 7.82 | 1.00 | 2.00 | 0.65 | 4.18 | |
| 25 - < 30 | 940,866 | 9,143 | 183 | 19.45 | 1.70 | 5.21 | 4.04 | 8.50 | |
| ≥ 30 | 302,958 | 3,721 | 86 | 28.39 | 0.99 | 4.62 | 12.21 | 10.56 | |
| Glucose [mmol/L] | < 5.55 | 1,789,414 | 9,034 | 154 | 8.61 | 0.78 | 2.29 | 0.45 | 5.09 |
| 5.55 - < 6.94 | 575,810 | 4,510 | 74 | 12.85 | 0.69 | 3.30 | 1.56 | 7.29 | |
| ≥ 6.94 | 654,077 | 8,245 | 158 | 24.16 | 2.45 | 5.50 | 9.02 | 7.19 | |
| Hypertension | No | 1,951,682 | 7,004 | 101 | 5.18 | 0.26 | 1.13 | 0.82 | 2.97 |
| Yes | 1,086,851 | 15,434 | 301 | 27.69 | 2.85 | 6.90 | 6.44 | 11.50 | |
| Triglycerides [mmol/L] | <1.17 | 1,440,477 | 6,803 | 74 | 5.14 | 0.56 | 1.18 | 0.62 | 2.78 |
| 1.17 - < 2.28 | 1,133,043 | 10,301 | 179 | 15.80 | 2.03 | 5.53 | 2.74 | 7.50 | |
| 2.28 - < 5.70 | 379,215 | 4,513 | 120 | 31.64 | 1.32 | 7.91 | 9.49 | 12.92 | |
| ≥5.70 | 31,541 | 400 | 24 | 76.09 | - | 25.36 | 25.36 | 25.36 | |
| Cholesterol [mmol/L] | <5.18 | 1,174,284 | 4,456 | 71 | 6.05 | 1.11 | 1.19 | 0.60 | 3.15 |
| 5.18 - < 6.22 | 985,051 | 7,215 | 123 | 12.49 | 1.22 | 3.15 | 2.94 | 5.18 | |
| ≥ 6.22 | 829,151 | 10,398 | 203 | 24.48 | 1.33 | 6.03 | 5.79 | 11.34 | |
| Gamma-GT [U/L] | normal | 2,604,467 | 16,474 | 297 | 11.40 | 1.19 | 2.92 | 1.69 | 5.61 |
| men: > 60 U/L, women: >35 U/L | 380,064 | 5,538 | 100 | 26.31 | 1.32 | 5.00 | 10.52 | 9.47 |
*per 100,000 person years;
– no patients in this subgroup;
ADPKD, autosomal dominant polycystic kidney disease; VN, vascular nephropathy; DN, diabetic nephropathy; BMI, body mass index.