Table 3. Hazard ratios (HR) for all-cause and cause-specific ESRD for discrete variables.
| Cause-specific ESRD | ||||||
|---|---|---|---|---|---|---|
| Risk factor | Categories | All-cause ESRD | ADPKD | VN | DN | Other disease |
| HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | ||
| N = 181,139* | 380 | 34 | 94 | 75 | 177 | |
| Sex | Women | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Men | 1.52 (1.23–1.93) | 0.90 (0.44–1.83) | 2.90 (1.79–4.73) | 0.88 (0.54–1.47) | 1.56 (1.13–2.15) | |
| Smoking status | Non-smokers | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Smokers | 1.32 (1.06–1.65) | 1.41 (0.68–2.94) | 1.81 (1.17–2.81) | 1.77 (1.07–2.91) | 0.98 (0.70–1.36) | |
| BMI [kg/m2] | <18.50 | 0.33 (0.05–2.36) | – | – | – | 0.51 (0.07–3.68) |
| 18.50 - < 25 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |
| 25 - < 30 | 1.16 (0.91–1.48) | 0.79 (0.37–1.67) | 1.11 (0.70–1.77) | 3.26 (1.41–7.53) | 1.08 (0.77–1.53) | |
| ≥30 | 1.43 (1.06–1.92) | 0.37 (0.10–1.23) | 0.89 (0.46–1.71) | 7.55 (3.23–17.61) | 1.19 (0.76–1.87) | |
| Glucose [mmol/L] | < 5.55 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| 5.55 - < 6.94 | 1.12 (0.84–1.48) | 0.82 (0.27–2.51) | 0.97 (0.56–1.68) | 2.29 (0.88–5.96) | 1.17 (0.81–1.69) | |
| ≥ 6.94 | 1.41 (1.12–1.78) | 2.51 (1.18–5.34) | 0.94 (0.59–1.51) | 7.67 (3.60–16.30) | 0.84 (0.58–1.21) | |
| Hypertension | No | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Yes | 2.61 (2.02–3.36) | 11.55 (4.22–31.60) | 2.37 (1.41–3.97) | 2.23 (1.20–4.14) | 2.29 (1.61–3.25) | |
| Triglycerides [mmol/L] | <1.17 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| 1.17 - < 2.28 | 1.88 (1.40–2.51) | 2.89 (1.22–6.69) | 1.70 (0.94–3.09) | 2.01 (0.89–4.78) | 1.82 (1.22–2.72) | |
| 2.28 - < 5.70 | 2.65 (1.90–3.69) | 1.92 (0.57–6.49) | 2.86 (1.48–5.53) | 3.73 (1.57–8.93) | 2.36 (1.47–3.81) | |
| ≥5.70 | 5.58 (3.35–9.32) | – | 9.27 (3.68–23.36) | 6.99 (2.26–21.63) | 4.36 (1.92–9.87) | |
| Cholesterol [mmol/L] | <5.18 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| 5.18 - < 6.22 | 1.13 (0.83–1.53) | 0.66 (0.29–1.48) | 1.24 (0.64–2.40) | 2.39 (0.98–5.80) | 1.06 (0.68–1.65) | |
| ≥6.22 | 1.22 (0.90–1.65) | 0.40 (0.16–1.02) | 1.26 (0.66–2.39) | 1.77 (0.73–4.30) | 1.56 (1.02–2.41) | |
| Gamma-GT [U/L] | Normal | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Men: > 60 U/L, Women: >35 U/L | 1.09 (0.85–1.39) | 0.81 (0.31–2.15) | 0.82 (0.48–1. 38) | 2.14 (1.33–3.43) | 0.92 (0.62–1.35) |
All models are adjusted for all risk factors and age (years);
*with full set of covariates;
– no patients in this subgroup;
ADPKD, autosomal dominant polycystic kidney disease; VN, vascular nephropathy; DN, diabetic nephropathy; CI, confidence interval; BMI, body mass index.