. 2016 Aug 18;11(8):e0160549. doi: 10.1371/journal.pone.0160549

Table 1. Summary of demographic and clinical characteristics of healthy eyes compared to glaucomatous eyes with and without localized RNFL defects visible on optic disc stereo photography.

Characteristics	Healthy 112 eyes(112 subjects)	Glaucoma with localized RNFL defect 47 eyes (47subjects)	Glaucoma without localized RNFL defect 102 eyes (102 subjects)	Different among three groups (P-value^*)
Age (years)	60.8 ± 10.1	63.5 ± 10.2	63.3 ± 10.3	0.132
Female gender n (%)	68 (61%)	33 (70%)	53 (52%)	0.097^**
Ancestry
European	38 (34%)	18 (38%)	40 (39%)	0.117^**
African	72 (64%)	24 (51%)	58 (57%)
Other	2 (2%)	5 (11%)	4 (4%)
Axial length (mm)	23.8 ± 0.9	23.7 ± 0.8	24.0 ± 1.0	0.154
CCT (μm)	540.5 ± 38.5	528.5 ± 43.5	535.3 ± 38.0	0.203
SAP MD (dB)	0.3 ± 1.1	-5.8 ± 5.7	-6.4 ± 6.6	< 0.001^†^‡
PSD (dB)	1.6 ± 0.4	7.3 ± 4.4	6.5 ± 4.3	< 0.001^†^‡
SAP VFI (%)	99.3 ± 0.8	81.9 ± 17.9	82.5 ± 19.4	< 0.001^†^‡
cpRNFL thickness (μm)	91.6 ± 10.0	71.7 ± 9.6	72.9 ± 15.0	< 0.001^†^‡
mGCIPL thickness (μm)	79.2 ± 6.6	68.3 ± 11.4	68.6 ± 11.2	< 0.001^†^‡

Values are mean ± standard deviation unless specified otherwise.

* p-values are based on one-way analysis of variance with post-hoc Scheffe for two groups

**Fisher’s exact test.

Abbreviations: CCT = Central corneal thickness; SAP = standard automated perimetry; MD = mean deviation; PSD = pattern standard deviation; VFI = visual field index; cpRNFL = circumpapillary retinal nerve fiber layer; mGCIPL = macular ganglion cell layer plus inner plexiform layer.

^† P indicate statistically significant differences between healthy eyes and glaucomatous eyes without localized RNFL defect using one-way analysis of variance with post-hoc Scheffe (p < 0.001).

^‡ P indicate statistically significant differences between healthy eyes and glaucomatous eyes with localized RNFL defect using one-way analysis of variance with post-hoc Scheffe (p < 0.001).