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. 2016 Jul 19;38(3):803–811. doi: 10.3892/ijmm.2016.2685

Figure 5.

Figure 5

Overexpression of ubiquitin-specific protease 4 (USP4) inhibits tumor growth an in vivo tumor model, and the downregulation of USP4 promotes tumor growth an in vivo model. (A) Representative tumors are presented from the experiments that were carried out using USP4-overexpressing BT549 and control cells. (B) Growth curves of mammary tumors after the injection of USP4-overexpressing BT549 and control cells into severe combined immunodeficient (SCID) mice. (C) Representative tumors were presented from the experiments that were carried out using MCF7 cells in which USP4 was silenced and control cells. (D) Growth curves of mammary tumors after the injection of MCF7 cells in which USP4 was silenced and control cells into SCID mice. **P<0.01, based on the Student's t-test. All results are from 3 or 4 independent experiments. Error bars indicate the means ± standard deviation.