Fig 5. Tissue specific tumorigenesis of Apc deletion.

(a) Characterization of Cre-mediated recombination in Tam-treated Tmprss2CreER^{T2/ T2}; Apc^LoxP/LoxP (TA) mice. Genomic DNA isolated from the indicated organs of a Tam-treated mouse were analyzed by PCR. The positions of the Apc floxed 498bp, and recombined 568bp DNA segments are indicated. (b) Gross pathology of colon of TA and wild-type mice following tamoxifen administration showing macroscopic colon polyps in tamoxifen treated mice. (c) H&E and β-catenin, Ki67 stain of TA and wild-type mouse colon. (d) H&E and β-catenin, Ki67 stain of TA and wild-type mouse prostate. Scale bars represent 100 μM.