Table 2. Univariate analyses of predictors for incidence of CKD.
| Variable | HR (95%CI) | p Value |
|---|---|---|
| Age (every 10 years) | 2.22 (1.70–2.94) | <0.0001 |
| Male | 2.41 (1.23–4.46) | 0.01 |
| Baseline eGFR (+5ml/min/1.73 m2) | 0.80 (0.71–0.90) | 0.0001 |
| CRP subgroups | ||
| Group1a | 1.00 (reference) | |
| Group2b | 2.04 (0.79–5.85) | 0.14 |
| Group3c | 3.50 (1.56–9.33) | 0.002 |
| Hypertension | 3.54 (1.91–6.95) | <0.0001 |
| Diabetes mellitus | 3.43 (1.66–6.52) | 0.002 |
| Dyslipidemia | 1.16 (0.61–2.11) | 0.63 |
| Overweight | 1.94 (1.07–3.46) | 0.03 |
| Smoking | 1.83 (0.79–3.72) | 0.14 |
| Disease duration of RA (1_year increment) | 1.02 (0.99–1.04) | 0.17 |
| Rheumatoid factor positive | 0.99 (0.49–2.29) | 0.99 |
| MTX | 0.44 (0.24–0.79) | 0.005 |
| Nephrotoxic DMARDs | 1.09 (0.62–1.95) | 0.76 |
| NSAIDs | 1.88 (1.06–3.45) | 0.03 |
Abbreviations: CKD, chronic kidney disease; HR, hazard ratio; CI, confidence interval;
CRP, C-reactive protein; RA, rheumatoid arthritis; MTX, methotrexate; DMARDs, disease modifying anti-rheumatic drugs; NSAIDs, nonsteroidal anti-inflammatory drugs.
Group 1a was defined as all three CRP values were ≤3.0 mg/L.
Group 2b was defined as one or two CRP values were >3.0 mg/L.
Group 3c was defined as all three CRP values were >3.0 mg/L.