Table 5. Multivariate adjusted hazard ratios for incidence of CKD according to the median CRP values along the entire follow-up.

	Model 1	Model 2	Model 3	Model 4
	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)
CRP subgroups
Low CRP a	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)
High CRP b	3.69 (1.85–7.99)	3.82 (1.92–8.29)	3.88 (1.93–8.50)	3.82 (1.86–8.51)

Abbreviations: CKD, chronic kidney disease; HR, hazard ratio; CI, confidence interval;

CRP, C-reactive protein.

Low CRP ^a was defined as median CRP values along the follow-up of ≤3.6 mg/L.

High CRP ^b was defined as median CRP values along the follow-up of > 3.6 mg/L.

Variables used for adjustment

Model 1; Age (every 10 years) and sex.

Model 2; Model 1 and baseline eGFR (+5ml/min per 1.73 m²).

Model 3; Model 2 and comorbidities (hypertension, diabetes, dyslipidemia, overweight, and smoking).

Model 4; Model 3 and drugs (MTX, nephrotoxic DMARDs and NSAIDs).