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. 2016 Jul 11;38(3):823–833. doi: 10.3892/ijmm.2016.2675

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Copyright: © Bao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of collagen α-5(IV) chain (Col4a5) knockdown on intracellular mycobacterial viability in RAW264.7 macrophages. (A–C) Control (VC) and cells in which Col4a5 had been knocked down (C51, C52 and C53) were infected with Mycobacterium tuberculosis (MTB) at an MOI of 3 and incubated for (A) 6 h, (B) 30 h (B) and (C) 72 h under either nutrient-enriched (GM) or starvation conditions (ST). (D–F) VC and cells in which Col4a5 had been knocked down (C51, C52 and C53) were infected with MTB at an MOI of 9 and incubated for (D) 6 h, (E) 30 h and (F) 72 h under either nutrient-enriched or starvation conditions. The numbers of MTB recovered from cell line lysates at different time points were measured as colony forming units (CFUs) ^*P<0.05 compared with VC.