Table 2. Mixed model linear regression estimates for circulating fasting serum FGF-21 levels (pg/mL) prior to and following each experimental period.

Model factor	estimate (CI lower, upper)	P-value*
Fixed effects
Intercept (10% protein, d 5)	300 (206, 394)
Slope (10% protein, d 1)	-153 (-260, -46)	0.02
Slope (15% protein, d 5)	-110 (-213, -6)	0.2
Slope (25% protein, d 5)	-251.64 (-355, -148)	<0.0001
Slope (15% protein d 1 to d 5)	131 (-15, 278)	0.2
Slope (25% protein d 1 to d 5)	194 (47, 340)	0.007
Intercept (15% protein, d 5)	190.0 (96, 284)
Slope (15% protein, d 1)	-21.45 (-129, 86)	0.4
Slope (25% protein, d 5)	-142.0 (6, 213)	0.0006
Slope (25% protein d 1 to d 5)	62.18 (-84, 209)	0.1
Intercept (25% protein, d 5)	48.0 (-46, 142)
Slope (25% protein, d 1)	40.73 (-66, 148)	0.2

*Square root transformation was used to normalise data for mixed model linear regression, untransformed data is presented.