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Biodistribution of free DOX, DOX-BSA-NPs and DOX-BSA-V-NPs in (A) heart and (B) tumor.
Notes: Time profiles of DOX accumulated in the (A) heart and (B) tumor after intravenous injection of different DOX formulations with a DOX dose of 5 mg kg−1. DOX/heart and DOX/tumor are the ratios of the DOX amount in the heart (μg) and tumor (μg) to the tumor weight (g), respectively. *P<0.05, **P<0.01.
Abbreviations: BSA, bovine serum albumin; DOX, doxorubicin; NPs, nanoparticles; V, vanillin.
