Table 4.

Influence of individual features on the 5-year disease-free survival of breast cancer patients

	Surgery (N = 713)			Neoadjuvant chemotherapy (N = 325)
Variables	TTP (months)	95% CI	P Log-Rank	TTP (months)	95% CI	P Log-Rank
Tumor Size (T)
T1	58.8 a	58.0 – 59.6		48.1 a	42.1 – 53.9
T2	56.5 a	55.2 – 57.8		50.0 a	47.2 – 52.7
T3	57.6 a	52.9 – 62.2	0.006	39.4	35.8 – 43.0	< 0.001
Lymph Node Status
Negative	59.1 a	58.4 – 59.8		50.5 a	46.3 – 54.7
Positive	56.1 a	54.7 – 57.5	< 0.001	44.8 a	42.3 – 47.3	0.02
Tumor grade (G)
G1	59.4 a	58.1 – 60.6		50.8 a	47.6 – 54.0
G2 + G3	57.0 a	56.1 – 57.9	0.02	43.7 a	41.2 – 46.2	0.006
ER or PR Status
Positive	58.0 a	57.3 – 58.7		47.9 a	45.5 – 50.3
Negative	54.0 a	51.3 – 56.7	< 0.001	37.7 a	33.3 – 42.11	< 0.001
Tumor Stage (TNM)
≤ IIA	55.8 a	54.1 – 57.5		51.4 a	47.2 – 55.5
≥ IIB	58.8 a	58.1 – 59.5	< 0.001	44.2 a	41.7 – 46.7	0.004
Adjuvant Treatment
Others	58.9 a	58.2 – 59.7		–	–	–
Chemotherapy	56.6 a	55.5 – 57.6	0.001	–	–	–
rs699947
CC	57.4 a	56.0 – 58.7		52.4	50.3 – 54.5
CA + AA	58.5 a	57.6 – 59.3	0.48	47.7	41.9 – 53.5	0.005
rs833061
TT	57.7 a	56.3 – 59.1		50.8	46.7 – 54.9
TC + CC	58.1 a	57.2 – 59.0	0.98	51.2	46.6 – 55.8	0.23
rs1570360
GG	57.9 a	56.8 – 59.2		51.8	47.4 – 56.2
GA + AA	58.0 a	56.9 – 59.1	0.85	50.4	45.6 – 55.2	0.23
rs2010963
GG	58.5 a	56.6 – 56.7		50.4	46.0 – 54.8
GC + CC	57.7 a	56.6 – 58.8	0.48	51.8	47.6 – 56.0	0.86
rs3025039
CC	58.4 a	57.6 – 58.7		50.8	47.1 – 54.5
CT + TT	56.9 a	55.1 – 58.7	0.17	51.3	46.2 – 56.4	0.66
Diplotype b
*1*1c	58.8 a	56.5 – 61.1		49.9 a	48.6 – 51.3
*1*2 + *2*2	57.4 a	55.7 – 59.1	0.54	51.8	45.6 – 57.9	0.08
*1*3 + *3*3	58.3 a	56.5 – 60.0	0.94	50.4	37.8 – 63.0	0.20
*1*4 + *4*4	58.1 a	54.8 – 61.2	0.87	53.0	38.9 – 67.1	0.69
*1*5 + *5*5	NC	NC	0.30	46.2 a	38.9 – 53.5	0.70

^aValues are presented as means, when medians were not achieved

^bDiplotypes formed by VEGFA haplotypes *1 to *5

^cReference diplotype. NC: Not calculated due to the lack of events.