Figure 7.
BALB/C nude mice (n = 6 per group) bearing Ketr-3 xenografts were treated with Ad5-ZD55, F5/35-ZD55, Ad5-ZD55-Hep27, F5/35-ZD55-Hep27 and PBS buffer control by intratumor injection five times every other day at a total dose of 100 (1×109pfu). Tumor size was measured every week. After 5 weeks treatment, mice were sacrificed and tumor mass were collected (A). Tumor growth curve was determined based on tumor size measured on the indicated day (B), * means P < 0.05, ** means P < 0.01. TUNEL assay was done to identify cell apoptosis mediated by adenovirus and the results showed that predominant apoptosis was observed. The tumor inhibition rate was also calculated and shown in C.