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HIF-1α inhibition by 2ME2 activates the mitochondrial apoptotic pathway. (A) AML cell lines were treated with 2.5μM of 2ME2 or 0.8mM of DMOG for 8 hours before measuring the intracellular ROS by dichlorodihydrofluorescein diacetate staining using flow cytometry. (B) AML cell lines were treated with the indicated concentrations of 2ME2, DMOG, shHIF-1α, or a combination of 2ME2 with NAC or DMOG. The relative protein expression of the genes were detected by Western blot.
