Skip to main content
. Author manuscript; available in PMC: 2017 Jan 4.
Published in final edited form as: Nat Chem Biol. 2016 Jul 4;12(9):694–701. doi: 10.1038/nchembio.2124

Figure 6. A model for Tbx16-dependent paraxial mesoderm patterning.

Figure 6

(a) Schematic representation of paraxial MPCs as they transition from proliferative to myogenic programs and migrate into the anterior presomitic mesoderm. Key factors associated with each developmental phase are indicated. (b) A proposed signaling network for the regulation of paraxial MPC renewal, movement, and differentiation. Our studies support a model in which Tbx16 suppresses the Ta/Wnt-dependent proliferation of epiblast MPCs and promotes their ingression into the presomitic mesoderm and differentiation into muscle. Tbx16 also regulates the timing of collinear hox gene activation, and the resulting hox codes coordinate the rates of MPC renewal, movement, and differentiation in space and time.