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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Endocr Relat Cancer. 2016 Jul 19;23(9):747–758. doi: 10.1530/ERC-16-0142

Figure 2.

Figure 2

Silencing the insulin receptor leads to decreased tumor growth. 8–10 week old Rag/WT control and Rag/MKR hyperinsulinemic mice were injected with either 5×106 LCC6 control (Ctrl) or 5×106 LCC6 insulin receptor knockdown (IRKD) cells, into the 4th mammary fat pad (n=8–10 mice per group). (A) Mammary tumor volume was calculated from tumor measurements taken twice weekly with calipers. * p<0.05 between Rag/MKR Ctrl and Rag/WT Ctrl tumors. ** p<0.05 between Rag/MKR Ctrl and Rag/MKR IRKD. # p<0.05 between Rag/WT Ctrl and Rag/WT IRKD tumors. N=8–10 mice per group, error bars represent SEM. (B) Tumor weight at the end of the study. (* p<0.05 between groups as indicated). N=8–10 mice per group, error bars represent SEM.