Table 4.
Antipsychotic (n=286) | Sedative-hypnotic (n=276) | Antidepressant (n=289) | ||||
---|---|---|---|---|---|---|
Domain Cluster | Adjustedb OR (95% CI) |
P value | Adjustedb OR (95% CI) |
P value | Adjustedb OR (95% CI) |
P value |
Delusions + Hallucinations + Agitationc | 1.12 (1.00–1.24) | 0.04 | X | X | X | X |
Caregiver distressd | 0.99 (0.80–1.24) | 0.96 | X | X | X | X |
Anxiety + Agitationc | X | X | 1.28 (1.06–1.55) | 0.01 | X | X |
Caregiver distressd | X | X | 0.89 (0.71–1.12) | 0.31 | X | X |
Depression + Apathyc | X | X | X | X | 0.97 (0.87–1.08) | 0.52 |
Caregiver distressd | X | X | X | X | 1.22 (0.99–1.50) | 0.07 |
Resides in nursing home (ref: no) | 9.47 (4.48–20.03) | <0.001 | 12.94 (4.43–37.78) | <0.001 | 14.62 (4.53–47.19) | <0.001 |
Dementia Stage | ||||||
Mild | ref | ref | ref | |||
Moderate | 6.90 (2.15–22.12) | 0.002 | 1.32 (0.37–4.76) | 0.66 | 2.74 (0.88–8.51) | 0.08 |
Severe | 3.29 (1.08–10.00) | 0.04 | 0.39 (0.09–1.59) | 0.18 | 1.51 (0.34–6.65) | 0.57 |
Odds ratio reflects odds of medication use relative to the no medication group. Medication groups are mutually exclusive.
Adjusted for age (linear term), gender, survey year, nursing home residence, and dementia stage.
Domain cluster variable is continuous and derived by adding the NPI scores for each domain listed in the cell. Odds ratio reflects the odds of medication associated with 1 additional NPI point from domains represented.
Caregiver distress variable is continuous and derived by adding the NPI caregiver distress scores for the respective participant domains.