Table 5. Pooled estimates of all studies comparing subfoveal choroidal thickness in normal pregnant eyes with normal control eyes.
| Subgroup | No. of studies | WMD (fixed) (95%CI) | Test for heterogeneity |
Test for overall effect |
||
| I2(%) | P | Z | P | |||
| All | 15 | 33.66 (26.16, 41.15) | 43.8 | 0.036 | 8.80 | <0.001 |
| Trimester | ||||||
| First trimester | 3 | 51.70 (36.09, 67.30) | 60.3 | 0.080 | 6.49 | <0.001 |
| Third trimester | 12 | 28.25 (19.70, 36.80) | 16.5 | 0.282 | 6.48 | <0.001 |
| Instrument | ||||||
| Spectralis | 8 | 43.21 (32.42, 53.99) | 47.0 | 0.067 | 7.85 | <0.001 |
| Cirrus-HD OCT | 7 | 24.74 (14.32, 35.16) | 0.00 | 0.438 | 4.65 | <0.001 |
| Pregnant | ||||||
| Healthy pregnant | 12 | 36.58 (28.42, 44.74) | 34.9 | 0.111 | 8.79 | <0.001 |
| Preeclampsia | 3 | 17.82 (-1.17, 36.82) | 58.7 | 0.089 | 1.84 | 0.066 |
WMD: Weighted mean differences; CI: Confidence interval; OCT: Optical coherence tomography.