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The pharmacokinetic profiles of cefoperazone (A) and sulbactam (B). The dots in (A,B) are the concentration determined by LC-MS/MS (before the first infusion on Day 4 and 0.5, 1, 2, 4, 6 h after the infusion), and the curves are the profiles fitted to the population pharmacokinetic model. The red lines were indicated the concentration for the MIC of AB1845.
