Table 3.
Descriptive statistics of CEA level in five determinations, depending on the occurrence of failures in treatment
| Subsequent CEA samples | 95%CI for Me | Mann-Whitney U testa | |||||
|---|---|---|---|---|---|---|---|
| Median | −95%CI | 95%CI | Min | Max | Z | p | |
| Total N = 316 | |||||||
| C_1 | 7 | 3.2 | 10.8 | 0 | 266 | ||
| C_2 | 9 | 5.6 | 12.4 | 0 | 344 | ||
| C_3 | 10 | 4.5 | 15.5 | 0 | 251 | ||
| C_4 | 9 | 2.5 | 15.5 | 0 | 212 | ||
| C_5 | 12 | 4.5 | 19.5 | 2 | 176 | ||
| Recurrence no N = 257 | |||||||
| C_1 | 7 | 4.8 | 9.2 | 0 | 134 | ||
| C_2 | 8 | 6.1 | 9.9 | 0 | 112 | ||
| C_3 | 9 | 5.4 | 12.6 | 0 | 176 | ||
| C_4 | 8 | 5.4 | 10.6 | 0 | 65 | ||
| C_5 | 10 | 1.3 | 18.7 | 2 | 176 | ||
| Recurrence yes N = 59 | |||||||
| C_1 | 10 | 0.0 | 27.7 | 1 | 266 | −3.094 | 0.002 |
| C_2 | 12 | 0.0 | 27.5 | 0 | 344 | −3.251 | 0.001 |
| C_3 | 16 | 0.0 | 36.8 | 0 | 251 | −3.816 | 0.000 |
| C_4 | 18 | 0.0 | 43.9 | 0 | 212 | −3.342 | 0.001 |
| C_5 | 12 | 3.8 | 20.2 | 7 | 40 | −1.310 | 0.190 |
| Meta no N = 248 | |||||||
| C_1 | 7 | 4.2 | 9.8 | 0 | 233 | ||
| C_2 | 8 | 6.0 | 10.0 | 0 | 87 | ||
| C_3 | 9 | 2.6 | 15.4 | 0 | 251 | ||
| C_4 | 8 | 0.5 | 15.5 | 0 | 212 | ||
| C_5 | 9 | 7.3 | 10.7 | 2 | 21 | ||
| Meta yes N = 69 | |||||||
| C_1 | 8.5 | 0.0 | 22.8 | 0 | 266 | −1.443 | 0.149 |
| C_2 | 12 | 0.0 | 25.5 | 0 | 344 | −3.462 | 0.001 |
| C_3 | 14 | 3.2 | 24.8 | 0 | 176 | −3.727 | 0.000 |
| C_4 | 17 | 4.6 | 29.4 | 4 | 142 | −4.190 | 0.000 |
| C_5 | 20.5 | 0.0 | 42.9 | 3.7 | 176 | −3.429 | 0.001 |
aMann-Whitney U test was used to compare the results of CEA level samples between groups of cured patients with patients with treatment failure (recurrence or distant metastasis)