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. 2016 Aug 12;7:12422. doi: 10.1038/ncomms12422

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Copyright © 2016, The Author(s)

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(a) Maximum intensity projections showing the distribution of Pdgfrb(BAC)-CreERT2-labelled GFP+ cells (green; arrows) in Fzd4^iΔPC mutant and littermate control (Pdgfrb(BAC)-CreERT2^+/T Fzd4^lox/+) E14.5 heart sections. Note profound reduction of GFP+ cells in Fzd4^iΔPC compact myocardium. (b) Statistical analysis of Fzd4^iΔPC versus control ventricle size, number of GFP+ cells in E14.5 compact myocardium and relative coverage of ventricle by GFP+ cells (n=8 in each group). Error bars,±s.e.m. P values, two-tailed unpaired t-test; NS, no significance. (c) Maximum intensity projections showing Pdgfrb(BAC)-CreERT2-labelled, GFP+ cells (green; arrows) in Ctnnb1^iΔPC mutant and littermate control (Pdgfrb(BAC)- CreERT2^+/T Ctnnb1^lox/+) E14.5 heart sections. GFP+ cells showed reduced migration to the apex and were less abundant in the Ctnnb1^iΔPC compact myocardium. (d) Statistical analysis of Ctnnb1^iΔPC versus control ventricle size, number of GFP+ cells in E14.5 compact myocardium and relative coverage of ventricle by GFP+ cells (Ctnnb1^iΔPC: n=7; control: n=8). Error bars±s.e.m. P values, two-tailed unpaired t-test; NS, no significance.