Table 3.

Meta-analysis of randomized studies on thrombectomy vs PCI alone.

Author	Number of trials analyzed	Number of patients	Follow-up period	Results
1. Bavry et al.56	30	6415	6 months	Aspiration thrombectomy reduced mortality while mechanical thrombectomy and distal embolic protection did not reduce mortality
2. Burzotta et al.57	11	2686	1 year	Manual thrombectomy improved 1 year survival. Additional benefit when patients treated with IIb/IIIa antagonist
3. Mongeon et al.58	21	4299	30 days	Mortality up to 30 days not reduced although ST resolution was better No reduction in recurrent MI/stroke
4. Tamhane et al.59	8 – manual device (Export, Pronto, Diver) 5 – mechanical device (Angiojet, X-Sizer) 4 – vacuum (Rescue TVAC)	3909	30 days	30 days mortality not reduced although MBG and TIMI flow 3 improved Stroke incidence increased in thrombectomy (14/1403) vs PCI alone (3/1413)
5. De Luca et al.60	21	4514	30 days	Manual thrombectomy improved ST resolution but did not reduce mortality Higher risk of stroke in thrombectomy patients within 30 days
6. Jolly et al.63	20 10	21,173 19,585	180 days 180 days	Mortality 3.8% in thrombectomy group vs 4.3% in PCI only group Stroke in thrombectomy group was 0.8% vs 0.5% in PCI only group
7. Elgendy et al.64	17	20,960	–	(1) No significant reduction in death, re-infarction with routine aspiration thrombectomy (2) Additional risk of stroke
8. Kumbhani et al.62	18 – manual aspiration 7 – mechanical thrombectomy	3936 1598 Total 5534	12 months	Manual aspiration but not mechanical thrombectomy beneficial in reducing MACE and mortality at 6–12 months
9. Deng et al.61	26	11,780	24 months	No evidence of definite benefit by manual aspiration although MACE was less frequent

MI, myocardial infarction; MBG, myocardial blush grade; TIMI, thrombolysis in myocardial infarction; PCI, percutaneous coronary intervention.