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. 2016 Aug 19;7:261. doi: 10.3389/fphar.2016.00261

Figure 4.

Figure 4

Curcumin suppressed neuroinflammatory response in APP/PS1 transgenic mice. Curcumin 150 mg/kg and PPARγ inhibitor GW9662 4 mg/kg were i.p. injected to APP/PS1 double-transgenic mice for 4 consecutive weeks. (A) IL-1β level in hippocampus. (B) TNF-α level in hippocampus. (C) COX-2 level in hippocampus. (D) NO level in hippocampus. Data were expressed as mean ± SD with six individual experiments. (E) Immunohistochemistry of GFAP in hippocampus. (F) Immunohistochemistry of Iba-1 in hippocampus. Representative sections of hippocampus from five mice were shown. (G) Western blot of GFAP in hippocampus. (H) Western blot of Iba-1 in hippocampus. A representative immunoblot from four mice was shown. Results were expressed as mean ± SD. *P < 0.05, **P < 0.01 vs. WT mice, #P < 0.05, ##P < 0.01 vs. APP/PS1 transgenic mice, ΔP < 0.05, ΔΔP < 0.01 vs. curcumin treated mice.