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Behavioral tests to determine cognitive function. (A) Novel object recognition test: Discrimination index of OT-II mice was significantly less than that for control mice in the test session, whereas discrimination indices of both groups in the familiarization ession were not different. (B) Y-maze: OT-II mice showed significantly less spontaneous alternation than control mice. Values are expressed as the mean ± SEM *p < 0.05, and ** p < 0.01 as compared to the control mice.
