Table 1. Baseline characteristics, related parameters and serum levels of CRP, S100A12, sRAGE and HMGB-1 in TB cases and controls.
| Variable | Case (n = 119) | Control (n = 163) | P value (Crude) | P value (Adjusted) |
|---|---|---|---|---|
| Age mean (SD), (Years) | 26 ± 11 | 32 ± 10 | <0.0001 | — |
| Sex No. (%), male/female | 58 (49)/61 (51) | 82 (50)/81 (49) | 0.81 | — |
| BMI mean (SD), (Kg/m2) | 16 ± 2.6 | 24 ± 4.5 | <0.0001 | <0.0001a |
| Smoking habits mean (SD), pack-year | 0.21 ± 0.83 | 0.07 ± 0.28 | 0.043 | 0.004a |
| Drinking habits No. (%), (yes/no) | 22 (19)/97 (81) | 3 (2)/160 (98) | <0.0001 | <0.0001a |
| Fasting blood glucose mean (SD), (mg/dL) | 97 ± 30 | 104 ± 30 | 0.06 | — |
| Blood pressure mean (SD), (mm/Hg) | ||||
| Systolic | 103 ± 15 | 123 ± 17 | <0.0001 | <0.0001a,b |
| Diastolic | 74 ± 10 | 80 ± 12 | <0.0001 | 0.97a,b |
| Cholesterol mean (SD), (mg/dL) | 167 ± 27 | 183 ± 33 | <0.0001 | 0.73b |
| LDL mean (SD), (mg/dL) | 104 ± 25 | 115 ± 25 | <0.0001 | 0.77b |
| HDL mean (SD), (mg/dL) | 41 ± 8.8 | 43 ± 33 | 0.37 | — |
| Tryglicerides mean (SD), (mg/dL) | 112 ± 38 | 136 ± 80 | 0.003 | 0.87b |
| Creatinine mean (SD), (mg/dL) | 0.91 ± 0.13 | 0.96 ± 0.17 | 0.005 | 0.77 b |
| CRP median (IQR), (mg/L) | 6.74 ± 2.15 | 3.18 ± 3.23 | <0.0001 | <0.0001a,b,c,d,e |
| TNF-α mean (SD), (pg/mL) | 13.4 ± 21.8 | 6.1 ± 20.4 | 0.004 | 0.02a,b,c,d,e |
| IFN-γ median (IQR), (pg/mL) | 7.0 ± 18 | 3.7 ± 11 | 0.17 | — |
| S100A12 mean (SD), (ng/mL) | 2.332 ± 1.631 | 1.090 ± 1.050 | <0.0001 | <0.0001a,b,c,d,e |
| sRAGE mean (SD), (ng/mL) | 0.74 ± 0.54 | 1.002 ± 0.563 | <0.0001 | 0.003a,b,c,d,e |
| esRAGE mean (SD), (ng/mL) | 0.06 ± 0.15 | 0.07 ± 0.10 | 0.65 | — |
| HMGB-1 median (IQR), (ng/mL) | 3.3 ± 5.5 | 3.0 ± 5.6 | 0.67 | — |
Adjusted for: aAge, bBMI, cSmoking habits, dDrinking habits and eSystolic BP by binary logistic regression. (SD) standard deviation, (IQR) interquartile range.