Figure 3. Differential gene expression in IECs of the F₁ generation induced by chronic inflammation in the F₀ generation.

(a) Heatmap showing hierarchical clustering of the top 50 differentially expressed genes (according to fold changes) in IECs between F₀^Ctrl and F₀^DSS mice. (b) Heatmap showing hierarchical clustering of the top 50 differentially expressed genes in IECs (according to fold changes) between F₁^Ctrl and F₁^DSS mice. Red and blue boxes indicate down-regulated and up-regulated genes, respectively. (c) Gene enrichment analysis of differentially expressed genes in the F₁ generation (P_adjusted< 0.05, absolute FC > 1). 1 = immune response, 2 = response to external biotic stimulus, 3 = defense response to other organism, 4 = response to other organism, 5 = response to biotic stimulus.