Figure 4. Treatment with human m336 antibody significantly attenuates lung pathology of mice challenged with MERS-CoV.

Lung specimens collected at day 2 post infection were fixed, appropriately processed, and H&E-stained for assessing the lung pathology. The lung pathology scores were graded from 0–3 (none, mild, moderate, and severe), based on the extent of mononuclear cell infiltration. Left: mice treated with 1 mg m102.4 control antibody 12 h prior to viral infection. Middle: mice treated with 1 or 0.1 mg of m336 antibody 12 h prior to viral infection as indicated. Right: mice treated with 1 or 0.1 mg of m336 antibody 12 h after viral infection as indicated.