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. 2016 Aug 19;6:31617. doi: 10.1038/srep31617

Table 1. The basic information of every studies included in this meta-analysis.

Polymorphismsand study Journal Year Ethnicity Sample size
 Genotypes
 Allele frequencies (%)
Cases Controls Cases Controls Cases Controls
rs1801274(FCGR2A)           AA AG GG AA AG GG A G A G
Vigato-Ferreira IC Autoimmunity 2014 Caucasian 157 160 23 59 75 35 43 82 0.334 0.666 0.353 0.647
Dijstelbloem HM Arthritis Rheum 2000 Caucasian 230 154 54 108 68 42 80 32 0.470 0.530 0.532 0.468
Zuñiga R Arthritis Rheum 2001 Caucasian 67 53 5 39 23 11 28 14 0.366 0.634 0.472 0.528
Seligman VA Arthritis Rheum 2001 Caucasian 76 186 10 49 17 28 114 44 0.454 0.546 0.457 0.543
Seligman VA Arthritis Rheum 2001 Caucasian 48 55 7 29 12 10 24 21 0.448 0.552 0.400 0.600
Manger K Ann Rheum Dis 2002 Caucasian 140 187 46 55 39 53 84 50 0.525 0.475 0.508 0.492
Botto M Clin Exp Immunol 1996 Caucasian 215 259 46 97 72 57 120 82 0.440 0.560 0.452 0.548
Duits A Arthritis Rheum 1995 Caucasian 95 69 18 50 27 22 36 11 0.453 0.547 0.580 0.420
Norsworthy P Arthritis Rheum 1999 Caucasian 195 283 32 96 67 62 131 90 0.410 0.590 0.451 0.549
Smyth LJ Ann Rheum Dis 1997 Caucasian 81 66 10 49 22 12 38 16 0.426 0.574 0.470 0.530
Smyth LJ Ann Rheum Dis 1997 Caucasian 42 52 14 16 12 20 24 8 0.524 0.476 0.615 0.385
González-Escribano MF Eur J Immunogenet 2002 Caucasian 276 194 64 137 75 59 86 49 0.480 0.520 0.526 0.474
Zhou XJ Lupus 2011 Asian 589 477 238 269 82 209 220 48 0.632 0.368 0.669 0.331
Kobavashi T J Periodontol 2007 Asian 71 44 34 31 6 28 16 0 0.697 0.303 0.818 0.182
Chu ZT Tissue Antigens 2004 Asian 163 129 72 70 21 53 58 18 0.656 0.344 0.636 0.364
Kyogoku C Arthritis Rheum 2002 Asian 193 303 113 72 8 197 95 11 0.772 0.228 0.807 0.193
Siriboonrit U Tissue Antigens 2003 Asian 87 187 37 40 10 93 76 18 0.655 0.345 0.701 0.299
Seligman VA Arthritis Rheum 2001 Asian 57 40 11 37 9 6 27 7 0.518 0.482 0.488 0.513
Salmon JE Arthritis Rheum 1999 Asian 148 97 70 66 12 41 47 9 0.696 0.304 0.665 0.335
Hatta Y Genes Immun 1999 Asian 81 217 49 30 2 139 71 7 0.790 0.210 0.804 0.196
Hatta Y Genes Immun 1999 Asian 69 93 42 26 1 62 28 3 0.797 0.203 0.817 0.183
Lee HS Rheumatology 2003 Asian 299 144 131 114 54 67 66 11 0.629 0.371 0.694 0.306
Botto M Clin Exp Immunol 1996 Asian 46 49 18 23 5 24 20 5 0.641 0.359 0.694 0.306
Yun HR Lupus 2001 Asian 300 197 132 114 54 82 99 16 0.630 0.370 0.668 0.332
Yap S Lupus 1999 Asian 175 108 59 91 25 28 63 17 0.597 0.403 0.551 0.449
Yap S Lupus 1999 Asian 50 50 20 26 4 21 21 8 0.660 0.340 0.630 0.370
Chen JY Ann Rheum Dis 2004 Asian 329 311 125 155 49 130 144 37 0.616 0.384 0.650 0.350
Zidan HE Mol Biol Rep 2014 African 90 90 20 45 25 22 50 18 0.472 0.528 0.522 0.478
Seligman VA Arthritis Rheum 2001 African 30 31 9 12 9 6 15 10 0.500 0.500 0.435 0.565
Botto M Clin Exp Immunol 1996 African 70 77 8 37 25 17 35 25 0.379 0.621 0.448 0.552
Seligman VA Arthritis Rheum 2001 mixed population 216 318 38 131 47 50 185 83 0.479 0.521 0.448 0.552
Seligman VA Arthritis Rheum 2001 Non-Caucasian 140 132 28 82 30 22 71 39 0.493 0.507 0.436 0.564
Salmon J J Clin Invest 1996 African Americans 43 39 4 23 16 14 15 10 0.360 0.640 0.551 0.449
Salmon J J Clin Invest 1996 African Americans 214 100 37 97 80 27 50 23 0.400 0.600 0.520 0.480
rs1050501(FCGR2B)           CC CT TT CC CT TT C T C T
Pradhan V Indian J Med Res 2011 Asian 80 80 16 49 15 10 52 18 0.506 0.494 0.450 0.550
Koga M J Hum Genet 2011 Asian 282 222 29 103 150 9 85 128 0.285 0.715 0.232 0.768
Willcocks LC PNAS 2010 Asian 819 1026 60 284 475 57 404 565 0.247 0.753 0.252 0.748
Kobavashi T J Periodontol 2007 Asian 71 44 4 26 41 0 6 38 0.239 0.761 0.068 0.932
Ji-Yih Chen Arthritis Rheum 2006 Asian 351 372 39 123 189 22 144 206 0.286 0.714 0.253 0.747
Chu ZT Tissue Antigens 2004 Asian 108 85 11 48 49 4 30 51 0.324 0.676 0.224 0.776
Kyogoku C Arthritis Rheum 2002 Asian 193 303 21 66 106 16 104 183 0.280 0.720 0.224 0.776
Siriboonrit U Tissue Antigens 2003 Asian 79 165 12 29 38 12 56 97 0.335 0.665 0.242 0.758
Magnusson V Arthritis Rheum 2004 Caucasian 263 228 7 67 189 4 53 171 0.154 0.846 0.134 0.866
Willcocks LC PNAS 2010 Caucasian 326 1296 9 48 269 13 232 1051 0.101 0.899 0.100 0.900
Li X Arthritis Rheum 2003 Caucasian 148 137 6 30 112 4 27 106 0.142 0.858 0.128 0.872
Zidan HE Mol Biol Rep 2014 African 90 90 32 39 19 17 44 29 0.572 0.428 0.433 0.567
Li X Arthritis Rheum 2003 African-American 160 149 14 49 97 17 53 79 0.241 0.759 0.292 0.708
rs396991(FCGR3A)           TT TG GG TT TG GG T G T G
Brambila-Tapia AJ Rheumatol Int 2011 Caucasian 94 98 61 5 28 52 8 38 0.676 0.324 0.571 0.429
Dong C Arthritis Rheumatol 2014 Caucasian 834 1185 392 370 72 517 564 104 0.692 0.308 0.674 0.326
Dijstelbloem HM Arthritis Rheum 2000 Caucasian 230 154 92 108 30 66 73 15 0.635 0.365 0.666 0.334
Zuñiga R Arthritis Rheum 2001 Caucasian 67 53 25 38 4 15 26 12 0.657 0.343 0.528 0.472
Seligman VA Arthritis Rheum 2001 Caucasian 78 207 37 30 11 55 102 50 0.667 0.333 0.512 0.488
Seligman VA Arthritis Rheum 2001 Caucasian 55 57 25 15 15 30 21 6 0.591 0.409 0.711 0.289
Manger K Ann Rheum Dis 2002 Caucasian 140 187 55 64 21 62 75 50 0.621 0.379 0.532 0.468
Wu J J Clin Invest 1997 Caucasian 200 113 87 92 21 29 69 15 0.665 0.335 0.562 0.438
González-Escribano MF Eur J Immunogenet 2002 Caucasian 276 194 101 131 44 66 104 24 0.603 0.397 0.608 0.392
Dai M Int J Rheum Dis 2013 Asian 732 886 376 308 48 381 427 78 0.724 0.276 0.671 0.329
Kobavashi T J Periodontol 2007 Asian 71 44 43 22 6 24 15 5 0.761 0.239 0.716 0.284
Chu ZT Tissue Antigens 2004 Asian 163 129 76 74 13 48 63 18 0.693 0.307 0.616 0.384
Kyogoku C Arthritis Rheum 2002 Asian 193 303 110 76 7 145 132 26 0.767 0.233 0.696 0.304
Siriboonrit U Tissue Antigens 2003 Asian 87 187 42 35 10 64 96 27 0.684 0.316 0.599 0.401
Seligman VA Arthritis Rheum 2001 Asian 59 41 22 29 8 12 22 7 0.619 0.381 0.561 0.439
Salmon JE Arthritis Rheum 1999 Asian 148 97 44 81 23 19 64 14 0.571 0.429 0.526 0.474
Hatta Y Genes Immun 1999 Asian 81 217 43 34 4 100 99 18 0.741 0.259 0.689 0.311
Hatta Y Genes Immun 1999 Asian 69 93 37 29 3 46 38 9 0.746 0.254 0.699 0.301
Lee EB Rheum Int 2002 Asian 145 75 89 51 5 40 29 6 0.790 0.210 0.727 0.273
Lee HS Rheumatology 2003 Asian 299 144 90 163 46 52 77 15 0.574 0.426 0.628 0.372
Yun HR Lupus 2001 Asian 300 197 90 164 46 71 104 22 0.573 0.427 0.624 0.376
Chen JY Ann Rheum Dis 2004 Asian 302 311 119 138 45 133 146 32 0.623 0.377 0.662 0.338
Dong C Arthritis Rheumatol 2014 African-American 648 953 289 283 76 413 431 109 0.664 0.336 0.659 0.341
Seligman VA Arthritis Rheum 2001 mixed population 233 348 97 96 40 108 172 68 0.622 0.378 0.557 0.443
Seligman VA Arthritis Rheum 2001 Non-Caucasian 155 141 60 66 29 53 70 18 0.600 0.400 0.624 0.376
Seligman VA Arthritis Rheum 2001 African 35 36 11 19 5 7 25 4 0.586 0.414 0.542 0.458
NA1/NA2           NA1·NA1 NA1·NA2 NA2·NA2 NA1·NA1 NA1·NA2 NA2·NA2 NA1 NA2 NA1 NA2
Kobavashi T J Periodontol 2007 Asian 71 44 20 46 5 20 19 5 0.606 0.394 0.670 0.330
Chu ZT Tissue Antigens 2004 Asian 163 129 46 90 29 41 74 14 0.552 0.448 0.605 0.395
Kyogoku C Arthritis Rheum 2002 Asian 193 303 62 98 33 116 145 42 0.575 0.425 0.622 0.378
Siriboonrit U Tissue Antigens 2003 Asian 87 187 30 39 18 85 82 20 0.569 0.431 0.674 0.326
Pradhan V Int J Rheum Dis 2010 Asian 80 80 20 32 28 18 32 30 0.450 0.550 0.425 0.575
Hatta Y Genes Immun 1999 Asian 81 217 23 38 20 92 100 25 0.519 0.481 0.654 0.346
Hatta Y Genes Immun 1999 Asian 69 93 18 33 18 44 39 10 0.500 0.500 0.683 0.317
Chen JY Ann Rheum Dis 2004 Asian 302 311 117 132 53 119 145 47 0.606 0.394 0.616 0.384
Dijstelbloem HM Arthritis Rheum 2000 Caucasian 230 154 42 101 87 27 66 61 0.402 0.598 0.390 0.610
Manger K Ann Rheum Dis 2002 Caucasian 140 187 13 87 40 20 87 80 0.404 0.596 0.340 0.660
González-Escribano MF Eur J Immunogenet 2002 Caucasian 276 194 30 77 169 20 75 99 0.248 0.752 0.296 0.704