Table 6. The allele frequency comparison between the meta-analysis and 1000 Genomes Project.
| Polymorphism | Populations | Meta-analysis(alleles frequencies) |
|
||||
|---|---|---|---|---|---|---|---|
| Cases |
Controls |
1000 Genomes(Alleles frequencies) |
|||||
| A | G | A | G | A | G | ||
| SNP rs1801274 | Caucasian | 0.445 | 0.555 | 0.474 | 0.526 | 0.500(EUR) | 0.5(EUR) |
| Asian | 0.652 | 0.348 | 0.697 | 0.303 | 0.722(ASN) | 0.278(ASN) | |
| African | 0.568 | 0.432 | 0.602 | 0.398 | 0.512(AFR) | 0.488(AFR) | |
| African Americans | 0.393 | 0.607 | 0.529 | 0.471 | 0.525(ASW) | 0.475(ASW) | |
| Mixed population | 0.479 | 0.521 | 0.448 | 0.552 | |||
| Non-Caucasian | 0.493 | 0.507 | 0.436 | 0.564 | |||
| All | 0.563 | 0.437 | 0.595 | 0.405 | 0.57(ALL) | 0.43(ALL) | |
| SNP rs1050501 | C | T | C | T | C | T | |
| Asian | 0.280 | 0.720 | 0.248 | 0.752 | 0.255(ASN) | 0.745(ASN) | |
| Caucasian | 0.128 | 0.872 | 0.107 | 0.893 | 0.123(EUR) | 0.877(EUR) | |
| African | 0.572 | 0.428 | 0.433 | 0.567 | 0.248(AFR) | 0.752(AFR) | |
| African-American | 0.241 | 0.759 | 0.292 | 0.708 | 0.213(ASW) | 0.787(ASW) | |
| All | 0.249 | 0.751 | 0.198 | 0.802 | 0.188(ALL) | 0.812(ALL) | |
| SNP rs396991 | T | G | T | G | T | G | |
| Caucasian | 0.659 | 0.341 | 0.629 | 0.371 | 0.731(EUR) | 0.269(EUR) | |
| Asian | 0.673 | 0.327 | 0.657 | 0.343 | 0.731(ASN) | 0.269(ASN) | |
| African-American | 0.664 | 0.336 | 0.659 | 0.341 | 0.713(ASW) | 0.287(ASW) | |
| Mixed population | 0.622 | 0.378 | 0.557 | 0.443 | |||
| Non-Caucasian | 0.600 | 0.400 | 0.624 | 0.376 | |||
| African | 0.586 | 0.414 | 0.542 | 0.458 | 0.785(AFR) | 0.215(AFR) | |
| All | 0.663 | 0.337 | 0.641 | 0.359 | 0.755(ALL) | 0.245(ALL) | |
EUR European ancestry, ASN Asian ancestry, AFR African ancestry, ASW Americans of African Ancestry, ALL All individuals from phase 1 of the 1000 Genomes Project.