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. 2016 Aug 19;6:31675. doi: 10.1038/srep31675

Figure 5. SPRY2 knockdown attenuates AREG-activated ERK1/2 signaling.

Figure 5

SVOG cells were transfected with 50 nM control siRNA (si-Ctrl) or SPRY2 siRNA (si-SPRY2) for 48 h and then treated with vehicle control (Ctrl) or 100 ng/mL AREG for 10 min. The levels of ERK1/2 phosphorylation and of SPRY2 expression were examined by western blot. The arrow indicates the SPRY2 band. The results are expressed as the mean ± SEM of at least three independent experiments. Values without a common letter are significantly different (p < 0.05).