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. Author manuscript; available in PMC: 2016 Aug 19.
Published in final edited form as: Sci Signal. 2016 Feb 2;9(413):ra12. doi: 10.1126/scisignal.aad3210

Fig. 3.

Fig. 3

Allosteric inhibition of ABL kinases decreases breast cancer bone metastasis.

(A) The experimental design. (B) Survival of mice after intracardiac injection of 1833 (1×105) breast cancer cells and treatment with either DMSO control or the allosteric ABL inhibitor GNF5. N=10 mice/group. (C) Bioluminescent images of representative mice at day 22 after inoculation. (D) Quantification of bone metastases. N=10 mice/group. (E–F) Representative HE staining (E) and quantification (F) of HE-stained tumor area of bone lesions. Arrows indicate tumor. N=3 mice/group. HE: Scale bar=200μM. (G–H) Representative Xray and μCT reconstruction (G) of mouse tibias and quantification (H) of bone volume/total volume. N=3 mice/group.